Embedded Files
C. Wilms’ tumor:
C. Wilms’ tumor:
Is the most common type of renal tumor in children. These often arise from the nephrogenic rests and are associated with Wilms Tumor gene (WT1/WT2).
History:
History:
3-year-old male patient presented with abdominal mass
Gross:
Gross:
1. Specimen of kidney shows a grey brown tumor mass at the upper pole
2. Cut surface shows a large, solitary, well circumscribed, grey brown tumor with areas of haemorrhage, necrosis and cystic change
Microscopy
Microscopy
Wilms' Tumor.png
1. Renal parenchyma with a malignant tumor.
2. Tumor is composed of blastemal cells, abortive tubules and mesenchymal component.
Diagnosis
Diagnosis
Wilms’ tumor
Key Questions & Answers
Key Questions & Answers
1) Describe the gross features of the specimen.
Specimen of kidney shows a tumor in the upper pole.
C/S shows solitary, well circumscribed grey brown tumor with areas of hemorrhage, necrosis and cystic change.
2) Identify the microscopic features of the given slide.
Renal parenchyma with a malignant tumor.
Tumor is composed of blastemal cells, abortive tubules and mesenchymal component.
3) Diagnose the pathological condition correlating the history, gross and microscopic features.
Wilms’ tumor
4) What are the syndromes associated with the above lesion?
Dennys Drash syndrome, WAGR syndrome, Beckwith Wiedemann syndrome
5) What is anaplasia in the context of this lesion?
Anaplasia is defined as the presence of cells with large, hyperchromatic, pleomorphic nuclei and abnormal mitoses.
Page updated
Google Sites
Report abuse