B. Renal cell carcinoma

Renal cell carcinoma:  

Are tumors that arise from tubular epithelium. The exact cause of RCC is not known. The associated risk factors include tobacco, obesity, hypertension, unopposed estrogen therapy, exposure to asbestos, petroleum, and heavy metals. An increased incidence is also noted in patients with chronic renal failure and acquired cystic disease. 

History:

60-year-old male patient presented with costovertebral pain, palpable mass, and hematuria 

Key Questions & Answers

1) Describe the gross features of the specimen.

1. Nephrectomy specimen

2. C/S shows grey white tumor involving the entire surface with areas of necrosis and extending into the renal vein 

2) Identify the microscopic features of the given slide.

1. Renal parenchyma with a malignant tumor.

2. Tumor cells arranged in sheets having clear cytoplasm, separated by thin branching vasculature and centrally placed nuclei.

3) Diagnose the pathological condition correlating the history, gross and microscopic features. 

Renal cell carcinoma (clear cell type)

4) What is the cell of origin of this lesion?

         Tubular epithelial cells

5) Mention the syndrome associated with the above lesion.

         Von Hippel Lindau syndrome