E. Peptic ulcer stomach

Peptic ulcer:

 Chronic ulcers that occur in any portion of GIT that is exposed to the aggressive action of acid and peptic juices. They result due to an imbalance between the mucosal defence mechanisms and damaging forces.

Common sites: 

Duodenum 1st part

Stomach –antrum / pylorus

Gastro esophageal (GE) junction

Margins of Gastrojejunostomy

Meckel’s diverticulum –ectopic gastric mucosa

Differences between Peptic ulcers and ulcer cancers

History:

 40 years old male presented with epigastric burning pain. 

Microscopy:

1. Zone of necrosis

2. Zone of inflammation

3. Zone of granulation tissue

4. Zone of fibrosis

Diagnosis

Peptic ulcer stomach

Key Questions & Answers

1) Describe the gross features of the specimen.

1. Specimen of gastrectomy shows small punched out ulcer with regular margin. 

2. Clean based ulcer.

2) Diagnose the pathological condition correlating the history & gross features. 

Peptic ulcer. 

3) What are the common sites of the above lesion. 

 Antrum of stomach, Ist part of duodenum, GJ Junction, Meckel`s diverticulum. 

4) Which are the complications of the above lesion.

            Bleeding, perforation, obstruction.

5). What are the features of malignant ulcer.

          Mucosal ulcer with  irregular heaped up margins with necrotic base.