A. Hodgkin’s lymphoma

A. Hodgkin’s lymphoma: 

These neoplasms are often localized to a single axial group of nodes (cervical, mediastinal, para-aortic) and shows an orderly spread by contiguity. It has a distinct morphological feature and is characterized by presence of neoplastic giant cells, the Reed-Sternberg (RS) cells. The RS cells release factors that induce accumulation of reactive lymphocytes, macrophages and granulocytes which typically make up the predominant cellularity of the tumor. These tumors can successfully be treated with radiotherapy and chemotherapy