D. Infarction spleen

Infarction Spleen: 

Is a condition in which blood supply to the spleen is compromised, leading to partial or complete death of the tissue. 

This results when the blood supply to the spleen is compromised, leading to partial or complete death of the tissue.

This could result when the splenic artery or its branches are affected by vasculitis or occluded by a blood clot. An increased tendency of clot formation is seen in certain infections, clotting disorders and in certain malignancies.

Splenic infarction is also common in hematological disorders with associated splenomegaly ( myeloproliferative disorders) and in certain conditions of splenomegaly (Gaucher disease or hemoglobinopathies). In sickle cell disease, splenic infarction is a common feature and repeated splenic infarctions lead to a non-functional spleen (autosplenectomy).

Also factors that directly compromises the splenic artery (trauma, aortic dissection, torsion of splenic artery) or external compression on the artery by a tumor can cause infarction 

Therapeutic splenic infarction: It is wherein splenic infarction is induced for the treatment of such conditions as portal hypertension. It can also be used before splenectomy for the prevention of blood loss.