C. Chronic venous congestion – spleen

C. Chronic venous congestion spleen: 

This results due to right heart failure, portal hypertension, which may be due to thrombosis of hepatic veins, cirrhosis, portal vein stenosis, thrombosis or splenic vein thrombosis. 

History:

70 year-old male patient presented with distension of abdomen. 

Key Questions & Answers 

1) Describe the gross features of the specimen.

1. Specimen of markedly enlarged and congested Spleen

2. C/S is diffusely dark reddish brown with thickened capsule

2) Mention the microscopic features of the given slide.

1. Splenic parenchyma with atrophied lymphoid follicles

2. Dilated and congested sinusoids

3. Areas of fibrosis with deposition of hemosiderin and calcification seen (Gamna gandy bodies)

3) Diagnose the pathological condition correlating the history, gross and microscopic features.

CVC Spleen

4) What are the common causes of this condition?

1. Cirrhosis of Liver

2. Portal and splenic vein thrombosis

3. Congestive cardiac failure

4. Right ventricular failure

5) What are the special stains used to demonstrate the bodies seen in this condition?

Gamna gandy bodies - Perl’s stain for Iron

  - Von Kossa for Calcium