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Actinomycosis:
Actinomycosis:
Actinomycosis is a chronic bacterial infection caused by filamentous, gram-positive, non–acid-fast, anaerobic bacteria. It is characterized by contiguous spread, suppurative / granulomatous inflammation, and formation of multiple abscesses with sinus tracts that may discharge sulfur granules. The most common clinical forms are cervicofacial, thoracic and abdominal.
Clinical presentation:
Clinical presentation:
Presents as abscess with draining sinuses, tissue fibrosis and occasionally as a soft tissue mass mimicking a tumor
Gross
Gross
Multiple subcutaneous abscesses with discharging sinuses extruding sulphur granules.
Microscopy:
Microscopy:
Actinomycosis.png
Basophilic actinomycotic colonies with Splendor-Hoepli eosinophilic material
Colonies surrounded by inflammatory cells composed of neutrophils, lymphocytes and plasma cells.
Diagnosis
Diagnosis
Actinomycosis
Key Questions & Answers
Key Questions & Answers
1. What is the causative organism?
The causative organism is Actinomyces israelii.
2. Mention the commonly affected sites.
It presents as cervical-facial, thoracic and pelvic lesions. The most common sites of infection are decayed teeth, lungs and intestines.
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