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Coagulative necrosis is a typical early response of living tissue to hypoxia, ischemia injury. The injury denatures not only structural proteins, but also lysosomal enzymes in the affected cell. It is most easily recognized in solid organs like liver, kidney, myocardium, or skeletal muscle.
Gross:
Gross:
1.Coagulative necrotic area appears pale tan to pale gray, often sharply demarcated from the normal color of adjacent viable tissue
2.It appears solid and firm (without apparent crumbling, sloughing, liquefaction, or other obvious loss of structure). The affected tissues take on a firm texture.
Microscopy:
Microscopy:
Myocardial Infarction (1).png
1. Cardiac fibers with retained cellular outlines (architecture), increased eosinophilic cytoplasm and loss of nuclei.
2. Neutrophilic infiltration seen between the necrosed cells and normal myocardial fibers
Diagnosis
Diagnosis
Myocardial infarction
Key Questions & Answers
Key Questions & Answers
1.What is the cause of coagulative necrosis
It is hypoxic injury/ ischemia
2.Mention the organs in which coagulative necrosis is seen
Coagulative necrosis is seen in solid organs like: Heart, Kidney and Spleen
3.Differences between necrosis and apoptosis
4.Differences between dry and wet gangrene
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