Chart-34

A 20 year- old- male presented with fever, malaise and jaundice. 

Interpret the results of Liver function tests. 

A. What is the diagnosis? Write two points in favour of your diagnosis. 

Diagnosis: Viral hepatitis

1. A 20 year- old- male having fever, malaise and jaundice with hyperbilirubinemia and markedly elevated SGOT and SGPT

2. Slightly elevated alkaline phosphatise and normal proteins, albumin and A:G ratio 

B. What are the important serological tests advised. 

Hepatitis A and E – IgM antibodies for acute infection

Hepatitis B  

Acute infection - HBs antigen, anti HBs antigen and anti HBc antigen (IgM)

Chronic infection - HBs ag + anti HBs ag (IgG)

Carrier state – HBe antigen

Hepatitis D 

Co-infection with HBV followed by full recovery - low titres of anti delta antibodies of IgM type.  

Co-infection with HBV in patients developing chronic hepatitis - High titres of anti delta antibodies of IgG type.    

Hepatitis C – IgM antibodies in acute infection and IgG in chronic infection

C. Name two transfusion associated hepatotropic viruses. 

1. Hepatitis B virus

2. Hepatitis C virus

3. Hepatitis D virus